Segregation of seizures and spreading depolarization across cortical layers
نویسندگان
چکیده
منابع مشابه
Interplay between Cortical Spreading Depolarization and Seizures.
Cortical spreading depolarization (CSD) is an electrophysiologic phenomenon found mostly in the setting of neurologic injury resulting in the disturbance of ion homeostasis and leading to changes in the local vascular response. The bioelectric etiology of CSD shares similarities to those in epileptic disorders, yet the relationship between seizures and CSD is unclear, with several studies obser...
متن کاملDifferent susceptibility of acutely injured and chronically epileptic brain tissue to induction of cortical spreading depolarization and seizures
Epileptic seizures and cortical spreading depolarization (CSD) are two patterns of electrophysiological activity that can be studied in the healthy and in the injured brain. They can be triggered by the same pathologies, such as stroke, traumatic brain injury and fever, with disruption of the blood brain barrier as a common hallmark. The latter is associated with entry of serum components into ...
متن کاملMechanisms of spreading depression and hypoxic spreading depression-like depolarization.
Spreading depression (SD) and the related hypoxic SD-like depolarization (HSD) are characterized by rapid and nearly complete depolarization of a sizable population of brain cells with massive redistribution of ions between intracellular and extracellular compartments, that evolves as a regenerative, "all-or-none" type process, and propagates slowly as a wave in brain tissue. This article revie...
متن کاملSpreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex
Spreading depolarization of cells in cerebral grey matter is characterized by massive ion translocation, neuronal swelling and large changes in direct current-coupled voltage recording. The near-complete sustained depolarization above the inactivation threshold for action potential generating channels initiates spreading depression of brain activity. In contrast, epileptic seizures show modest ...
متن کاملCortical spreading depression and peri-infarct depolarization in acutely injured human cerebral cortex.
Electrocorticographic (ECoG) activity was recorded for up to 129 h from 12 acutely brain-injured human patients using six platinum electrodes placed near foci of damaged cortical tissue. The method probes ECoG activity in the immediate vicinity of the injured cortex and in adjacent supposedly healthy tissue. Six out of twelve patients displayed a total of 73 spontaneous episodes of spreading de...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2019
ISSN: 0013-9580,1528-1167
DOI: 10.1111/epi.16390